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李洪凯 研究员

发布者:李洪凯 发表时间:2020-06-08 来源: 浏览次数:

个人简历

 


个人信息

姓名:李洪凯 

邮箱:lihongkaiyouxiang@163.com

联系地址:济南市市中区二环东路12550号国家健康医疗大数据研 

                    究院

李洪凯,国家健康医疗大数据研究院大数据因果推断中心主任,彩票平台公共卫生学院正高级研究员,山东省产业技术研究院特聘研究员。中国现场统计研究会因果推断分会常务理事,中国工业统计研究会健康医疗大数据学会理事,山东省脑胶质瘤多学科联合委员会委员。主要研究方向包括未知混杂的控制方法、因果推断框架下的数据整合,中介效应分析,测量误差和选择性偏倚的控制方法以及统计遗传方法学研究。彩票平台在国际知名杂志发表SCI文章60余篇(JCR一区论文 15 篇),其中第一和通讯作者文章20篇。主要研究成果发表彩票平台在Plos Genetics, Statistical Methods in Medical Research, Statistics in Medicine,American Journal of Epidemiology等统计理论方法杂志以及British Journal of Cancer, Atherosclerosis,Obesity, Journal of American Heart Association 等临床应用杂志上, 同时也是Plos Medicine, International Journal of Epidemiology等多个杂志审稿人。主持国家自然科学基金和科技部重大专项子课题等7项国家级和省部级课题,参编书籍三部。

教育背景和工作经历

2022.11-彩票平台健康医疗大数据研究院 研究员

2019.3-现彩票平台在 国家健康医疗大数据研究院 大数据因果推断中心 主任

2017.4-2019.3 北京大学数学与信息科学学院  博士后  导师 耿直

       研究方向: 因果推断和数据融合方法

2011.9-2016.12彩票平台流行病与卫生统计学(生物统计)  硕博连读  导师 薛付忠

       研究方向:系统流行病学框架下的因果推断理论与方法研究

2013.12-2014.6 纽约城市大学生物统计系联合培养博士   导师   杨晓伟

研究方向:生物统计学。基于多种组学数据(基因表达、甲基化,GWAS,蛋白数据等)的贝叶斯变量选择。


研究兴趣

(1)多个数据库的因果数据融合方法研究;

(2)测量偏倚、选择性偏倚和混杂偏倚的控制方法研究;

(3)迁移学习,尤其是实验研究向目标人群的迁移和两个观察人群的迁移方法研究;

(4)孟德尔随机化方法和多中介以及结构学习方法研究;

(5)因果框架下的meta分析和网络meta分析方法研究;

(6)遗传关联与共定位方法研究

(7)时间序列框架下的因果推断方法研究


项目经历

1. 科技部重大专项基于临床的中药安全风险发现、评价、控制策略及关键技术研究,2022YFC35021002020.07 - 2023.06 1391万,彩票平台在研,课题负责人

2. 国家自然基金青年基金项目,82003557,因果机制下系统流行病学的跨组学因果调控网络特定通路推断和多重靶向干预的方法研究,2021.1-2023.12, 24万,彩票平台在研,主持

3. 横向基金,有源医疗器械不良事件风险信号挖掘评价方法研究,2021.9-2022.96万,主持

4. 国家自然基金面试项目,82173625,大数据背景下循证因果迁移学习的统计分析方法,2022.1-2025.1255万,彩票平台在研, 参与

5. 国家自然科学基金面上项目,11771028,因果推断方法研究及彩票平台在食品安全及彩票平台在生物医学中的应用,2018.01-2021.1248万,彩票平台在研, 参与

6. 国家自然科学基金面上项目,81573259,系统流行病学中网络差异比较的统计分析方法研究,2016.01-2019.12,72万,彩票平台在研, 参与

7. 国家自然科学基金面上项目,81273177,基于贝叶斯竞争风险理论的农村人群脑卒中发生和转归的适宜性风险预警策略与方法研究,2013.01-2016.12,60万元,已结题,参与

8. 国家自然科学基金青年项目,31200994,全基因组关联分析中基因-基因交互网络比较的统计推断方法研究,2013.01-2015.12,20万,已结题, 参与


学术会议

2020年11月,中国人民大学临床统计会议,会议报告

2020年10月,首都医科大学健康大数据会议,会议报告

2019年9月,苏鲁皮肤会议(镇江),会议报告

2019年9月,健康管理学会议(北京),会议报告 

2019年8月,中国生物统计年会(广州),会议报告

2018年6月,京津冀概率论与统计学术研讨会(北京), 参加

2016年7月,中国卫生统计学术年会(天津),会议报告和poster

2015年6月,参加泛华统计学年会(上海),会议报告

2015年6月,中国卫生统计学术年会(太原),会议报告

2015年5月,统计遗传与基因组学国际研讨会(太原),参加

2014年7月,中国卫生统计(生物统计)学术年会(广州),参加

2013年8月,中国卫生统计学术年会(济南),参加


学术活动

山东省齐鲁医院血液科学术报告:控制测量误差和未知混杂的工具辅助变量方法

山东省千佛山医院麻醉科:因果推断方法简介

山东省省立医院护理学:临床统计方法培训及SPSS实现

山东省眼科医院:临床研究中的统计方法

彩票平台第二医院:因果推断方法简介

广东省汕头大学医学院:因果推断中心介绍

山东省省立医院内分泌科:因果推断

山东省精神卫生中心 流行病学设计和因果推断

彩票平台第二医院内分泌科: 观察性研究中的因果推断

彩票平台基础医学院 创新论坛  因果推断

彩票平台护理与康复学院  医学研究中的统计方法


方法彩票平台文章

[1] R Yan#, YY Yu#,HK Li*, FZ Xue*. Selection bias in Negative control study and its correction method.

[2] YY Yu#, Lei Hou#, HK Li*, FZ Xue*, Impact of Nonrandom Selection Mechanisms on the Causal Effect Estimation for Two-sample Mendelian Randomization Methods. PLoS Genet. 2022 Mar 17;18(3):e1010107. [JCR 一区]

[3] Li H#, YY Yu#, FZ Xue, et al. A negative control outcome regression method for controlling unobserved confounding and lagged effect in time series. American Journal of Epidemiology [Submitted].

[4] Liu X, Yang J, Li H, Wang Q, Yu Y, Sun X, Si S, Hou L, Liu L, Yang F, Yan R, Yu Y, Fu Z, Lu Z, Li D, Xue H, Guo X, Xue F, Ji X. Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions. BMC Cancer. 2022 Nov 19;22(1):1194.

[5] Li H, Jia J, Yan R, Xue F, Geng Z. A causal data fusion method for the general exposure and outcome. Stat Med. 2022 Jan 30;41(2):328-339. doi: 10.1002/sim.9239. Epub 2021 Nov 2. PMID: 34729799. [JCR 二区]

[6] Li H#,Hou L#, Xue F*et al. A multiple negative control regression to control unobserved confounding. Epidemiology. [Under Review]

[7] Li H#,Xinhui Liu#,Hou L, Xue F*.A novel instrumental variable to control measurement error and unobserved confounding.Statistical Method in Medical Research.[Under Review]

[8] YuanyuanYu#,Li H#,Hou L, Xu M, Yu Y, Sun X, Liu X, Liu L, Li Y, Yuan T, Li W, Xue F*.The identification and estimation of causal effect using a Negative control exposure in time series studies with application to environment epidemiology. American Journal of Epidemiology. 2020 Aug 24;kwaa172. [JCR 一区]

[9] Hou L, Yu Y, Sun X, Liu X, Yu Y, Li H*, Xue F*. Causal mediation analysis with multiple causally non-ordered and ordered mediators based on summarized genetic data. Stat Methods Med Res. 2022 Jul;31(7):1263-1279. [JCR一区]

[10] Lu Liu#,Hou L#, Xu M, Yu Y, Sun X, Liu X, Liu L, Li Y, Yuan T, Li W,Li H*, Xue F*. A double confounders method to eliminate unobserved confounding. BMC Medical Research Methodology. (2020) 20:195 [JCR一区]

[11] Li H,Xu M, Yu Y, Sun X, Liu X,Xue F. A novel path-specific effect statistic for identifying the differential specific paths in systems epidemiology. BMC Genetics. 21,85 (2020).

[12] Li H, Miao W, Cai Z, Liu X, Zhang T, Xue F, Geng Z. Causal data fusion methods using summary-level statistics for a continuous outcome. Statistics in Medicine. 2020 Apr 15;39(8):1054-1067.[JCR二区]

[13] Yu Y#, Li H#, Sun X, Su P, Wang T, Liu Y, Yuan Z, Liu Y, Xue F. The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams. BMC Med Res Methodol. 2017 Dec 28;17(1):177. doi: 10.1186/s12874-017-0449-7.[JCR一区]

[14] Wang T#,Li H#, Su P, Yu Y, Sun X, Liu Y, Yuan Z, Xue F. Sensitivity analysis for mistakenly adjusting for mediators in estimating total effect in observational studies.BMJ Open. 2017 Nov 20;7(11):e015640.

[15] Li H, Zhongshang Yuan, Jiadong Ji, Jing Xu, Tao Zhang, Xiaoshuai Zhang, and Fuzhong Xue. A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data. BMC Genet. 2016; 17: 51.

[16] Li H, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun, Fuzhong Xue. A simulation study on matched case-control designs in the perspective of causal diagrams. BMC Medical Research Methodology. 2016; 16:102.[JCR一区]

[17] Xu J, Yuan Z, Ji J, Zhang X,Li H, Wu X, Xue F, Liu Y. A powerful score-based test statistic for detecting gene-gene co-association.BMC Genet.2016;17(1):31.

[18] Xiaoshuai Zhang; Zhongshang Yuan; Jiadong Ji;Li H; Fuzhong Xue. Network orregression-based methods for disease discrimination A comparison study. BMC Medical Research Methodology.BMC Medical ResearchMethodology, 2016;16(1): 100. [JCR一区]

[19] Ji J, Yuan Z, Zhang X, Li F, Xu J, Liu Y,Li H, Wang J, Xue F. Detection for pathway effect contributing to disease in systems epidemiology with a case-control design. BMJ Open. 2015 Jan 16;5(1):e006721. 2014.

[20] Xinhui Liu#, Hongkai Li#, Fuzhong Xue. Detection, reduction and correlation of unobserved confounding in the presence of an error-prone negative control exposure: bias analysis and correction methods. Epidemiology. [Revision]. [JCR一区]


应用彩票平台文章

[1] H Xue, HK Li, FZH Xue, Gang Li et al.Evaluation the liquid biopsy efficacy of cerebrospinal fluid small extracellular vesicles miRNAs as biomarkers of glioma early recurrence monitoring.

[2] Lei Hou#Li H#, et al.Causal Effects of Bilirubin on CVD and Diabetes in the UKBiobank Cohort Study: Observational findings and Mendelianrandomization studies.Atherosclerosis. [Accept] [JCR 一区]

[3] Li H#, Lei Hou#,et al.Education and risks of breast cancer in women: a Mendelian randomisation analysis.Cancer medicine. [Submitted]

[4]Shucheng Si, Li H, Fuzhong Xue, et al.Causal pathways from body components and regional fat to extensive metabolic phenotypes: Mendelian randomization study. Obesity. [Accept] [JCR一区]

[5] Wenchao Li,Li H, et al.基于孟德尔随机化探索臀围与2型糖尿病的因果关系.2020.中华疾病控制杂志。

[6] Xinhui Liu, Li H, et al.腰围和冠心病因果关系的孟德尔随机化研究。2020,彩票平台学报。

[7] Chuan Wang, Li H, et al.Serum Metrnl Level is Correlated with Insulin Resistance, But Not withb-Cell Function in Type 2 Diabetics. November 2019.Medical science monitor: international medical journal of experimental and clinical research25:8968-8974.

[8] Hou L, Xu M, Yu Y, Sun X, Yuan T, Li W,Li H*, Xue F*.Exploring the causal pathway from ischemic stroke to atrial fibrillation: a network Mendelian randomization study. Mol Med. 2020 Jan 15;26(1):7.[JCR二区]

[9] Zhang D, Yang Y, Wu M, Zhao X, Sun Y, Xie H, Li H, Li Y, Wang K, Zhang J, Jia J, Su Y. The moderating effect of social support on the relationship between physical health and suicidal thoughts among Chinese rural elderly: A nursing home sample. Int J Ment Health Nurs. 2018 Oct;27(5):1371-1382. [JCR一区]

[10] Zhang Y, Zhang T, Zhang C, Tang F, Zhong N, Li H, Song X, Lin H, Liu Y, Xue F. Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population. BMJ Open. 2015 Sep 22;5(9):e008204.

[11] Liu Y, Wang X, Pang C, Yuan Z, Li H, Xue F. Spatio-temporal analysis of the relationship between climate and hand, foot, and mouth disease in Shandong province, China, 2008-2012.BMC Infect Dis. 2015 Mar 24;15:146. doi: 10.1186/s12879-015-0901-4.

[12] Zhang T, Zhang C, Zhang Y, Tang F, Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F. Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: a prospective cohort study. Atherosclerosis. 2015 May;240(1):144-8.[JCR一区]

[13] Ni W, Ding G, Li Y,Li H, Jiang B. Impacts of floods on dysentery in Xinxiang city, China, during 2004-2010: a time-series Poisson analysis. Glob Health Action. 2014 Aug 5;7:23904.

[14] Ni W, Ding G, Li Y,Li H, Liu Q, Jiang B. Effects of the floods on dysentery in north central region of Henan Province, China from 2004 to 2009.J Infect. 2014 Nov;69(5):430-9.[JCR一区]

[15] Zhang T, Zhang Y, Zhang C, Tang F, Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F. Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study. PLoS One. 2014 May 6;9(5):e96651.

[16] Jiate Wei, Yunxia Liu, HK, Li, et al .Impacts of Transportation and Meteorological Factors on the Transmission of COVID-19 August 2020. International Journal of Hygiene and Environmental Health 230:113610. [JCR一区]

[17] Shucheng Si, Lei Hou, Hongkai Li, Fuzhong Xue, etc. Si S, Li J, Li Y, et al. Causal Effect of the Triglyceride-Glucose Index and the Joint Exposure of Higher Glucose and Triglyceride With Extensive Cardio-Cerebrovascular Metabolic Outcomes in the UK Biobank: A Mendelian Randomization Study[J]. Frontiers in cardiovascular medicine, 2021: 387. [JCR二区]

[18] Shucheng Si, Lei Hou, Xiaolu Chen, Hongkai Li, Fuzhong Xue et al. Exploring the causal roles of circulating remnant lipid profile on cardiovascular and cerebrovascular diseases: Mendelian randomization study. Journal of Epidemiology. [JCR二区]

[19] Qing Wang, Hongkai Li, Fuzhong Xue, et al. Effects on Hypertension Control of Distributing Essential Medicines at No Charge: A Quasi-Experimental Study in Rural Communities of China. SSRN Electronic Journal.

[20] Liu X, Li C, Li H*, Xue F*. Liu X, Li C, Sun X, et al. Genetically predicted insomnia in relation to 14 cardiovascular conditions and 17 Cardiometabolic risk factors: a Mendelian randomization study[J]. Journal of the American Heart Association, 2021, 10(15): e020187. [JCR 一区]

[21] Shucheng Si, Hongkai Li, Fuzhong Xue. Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers. October 2021.British Journal of Cancer.  [JCR 一区]